City of Irvine Partners with Edwards Lifesciences, Providence, Santa Ana, Costa Mesa & Tustin to Open COVID-19 Vaccination Clinics

Wednesday, April 21, 2021

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The City of Irvine is partnering with Edwards Lifesciences, the Orange County-based medical technology company, Providence, a national nonprofit health system, and the cities of Santa Ana, Costa Mesa, and Tustin to open two mass vaccination clinics at one of Edwards Lifesciences’ campus buildings in Santa Ana and the Orange County Great Park in Irvine, providing convenient access for residents to protect themselves from COVID-19.

The Providence clinic at the Edwards Lifesciences site, which was made possible in part by a generous $500,000 donation from the company as well as significant facility and staffing support, was strategically chosen due to its capacity and central location. The clinic opens today at 3009 Daimler St. in Santa Ana. A second Providence vaccination clinic in partnership with the City of Irvine will open at the Orange County Great Park Monday, April 26. The drive-thru clinic at 8000 Great Park Blvd. will offer residents convenient access to life-saving vaccines from the comfort of their vehicles. 

“My unwavering commitment to bring a vaccine clinic to Irvine serving the needs of Irvine residents has come to fruition,” said Mayor Farrah N. Khan. “Through my COVID-19 Task Force and regional City partnerships, we will meet the needs of Irvine and Orange County residents by providing easy and convenient access to this life-saving vaccine. This is a pivotal step in returning our City to a prosperous and thriving community and destination.”

Vaccines are by appointment only and can be scheduled at or by calling 1-833-422-4255. Free parking is available adjacent to the clinic location at Edwards. 

To ensure smooth operation of the sites, the City of Irvine, along with the neighboring cities of Santa Ana, Costa Mesa, and Tustin, are providing resources, including public safety and equipment. Through targeted outreach and multilingual communications, the cities are also working to overcome accessibility challenges and immunization hesitancy within their local communities. 

“Providence is committed to providing Orange County residents with access to the vaccine, particularly our most vulnerable communities that are bearing the brunt of this virus, and our strong partnerships are making that possible. Working with the dedicated staff at Edwards and the Cities of Irvine, Santa Ana, Costa Mesa, and Tustin to open these two sites helps us increase our capacity to deliver more vaccine doses and keep our communities healthy,” said Erik G. Wexler, president, operations and strategy, Providence - South.

Providence has helped lead vaccine distribution in the region, having administered more than 256,815 doses to date. Providence clinical and operations teams will staff the mass vaccine clinics, and through its regional operations, have access to the three U.S. Food and Drug Administration-approved COVID-19 vaccines from Pfizer BioNTech, Moderna, and Janssen (Johnson & Johnson). Following the recommendation from the Centers for Disease Control and Prevention and the U.S. Food and Drug Administration, Providence has paused use of the Johnson & Johnson vaccine. Once fully operational, the two sites together will be able to vaccinate up to 4,000 residents per day, with the ability to expand depending on vaccine supply. All vaccines are administered free of charge.

Since the onset of the COVID-19 pandemic, there have been over 44,000 diagnosed cases of COVID-19 in Santa Ana, equating to a 13.2% positivity rate. Neighboring cities have faced lower but still high positivity rates, with Irvine having a 3.6% positivity rate; Tustin, 7.49%; and Costa Mesa, 7.59%. Furthermore, communities of color continue to be disproportionately impacted by COVID-19.

Providence is committed to helping reduce health disparities exacerbated by the pandemic and recently made an initial investment of $1.4 million to expand outreach and education and increase the COVID-19 testing and vaccination supply to marginalized communities. In addition to pop-up vaccine clinics in at-risk communities, Providence hopes these two new mass clinics will help support the equitable distribution of vaccines across the county. 

For additional information about the Orange County Great Park vaccination site or Irvine-related COVID-19 resources, please visit

Category: COVID-19, City of Irvine